各位老师，您好：由实验室罗跃嘉老师邀请了University of California, San  Francisco的苑克鑫来实验室做报告，欢迎感兴趣的老师来听！祝好~~

报告题目： Cortical circuits: focusing  on inhibition报告人：苑克鑫报告时间：6月21日（下周二）上午10点报告地点：小楼三楼大会议室
报 告摘要：Growing evidence  indicates that global excitatory-inhibitory imbalances or specific anomalies in  defined inhibitory neuron types are associated with broad neurodevelopmental or  neuroplastic disorders such as schizophrenia or autism, as well as with  specifically auditory disorders such as tinnitus or hyperacusis. Abnormalities  in cortical auditory processing, both spontaneous and evoked, are prominent  symptoms of schizophrenia, and auditory processing abnormalities such as  auditory hypersensitivity or tinnitus are extremely frequent in autism.  Understanding the relationships between these cellular and functional anomalies  requires a detailed understanding of inhibitory neurons' interactions during  normal cortical operation.

Toward this direction, we have made some  exciting progresses. In this talk, I will first demonstrate how inhibitory  circuits are specifically organized at large network scale in accordance with  certain function modules in auditory cortex. I will then show how cortical  excitation and inhibition interact with each other at local circuit level. Most  importantly, I will show how the balance between excitation and inhibition is  established and calibrated during the critical period of brain development, and  how progressive, experience-dependent refinement of intracortical inhibition set  the pace of cortical synaptic receptive field development. Finally, I am going  to show you how my future studies will reveal the functional roles of cortical  inhibition in complex sensory stimuli processing, and their modulation and  control by bottom-up and top-down signals. My ultimate goal is to ask following  fundamental questions: what computations can different types of inhibitory  neurons perform? How does each type’s activation affect input integration in its  targets? Under what behavioral or sensory conditions are the different  inhibitory neurons activated? How can long-range or neuromodulatory inputs  dynamically regulate these interactions, and how does this match  moment-to-moment changes in cognitive or behavioral  requirements?


报告人简历：
EDUCATION
2001-2006          Ph.D.     Neuroscience, Institute of Biophysics,  Chinese  
                                    Academy of Sciences, Beijing,  China       

1997-2001         B.S.            Biochemistry, Yantai University, Yantai, China
RESEARCH  EXPERIENCE 2009-Present             Post-doc, University of California, San  Francisco
2006-2008        Post-doc, University of California, San  Francisco
Post-doc, University of California, Berkeley
SELECTED   PUBLICATIONS
1.      Kexin Yuan, Junxian Shen. (2011) Columnar and  layer-specific representation of azimuth sensitivity in mouse primary auditory  cortex. NeuroReport. (Accepted)
2.      Dorrn, A.L.*, Yuan, K.*, Barker,  A.J., Schreiner, C.E., and Froemke, R.C. (2010) Developmental sensory experience  balances cortical excitation and inhibition. Nature. 465:932-936. * Equal  contribution.
3.      Kexin Yuan, Kathren L. Fink, Jeffery A. Winer,  Christoph E. Schreiner. (2010) Local connection patterns of parvalbumin-positive  inhibitory interneurons in rat primary auditory cortex. Hearing Research.  274(1-2):121-128.
4.      Kexin Yuan, Junxian Shen. (2005) Auditory cortical  neurons in the mouse have salient best azimuths. NeuroReport. 16:  2007-2010.


                  此致
敬礼！

                                     杨静
                                2011.06.16