各位老师，您好：

由实验室贺永老师邀请了来自美国Albert Einstein College of Medicine,  Yeshiva University的李小波教授来做报告，欢迎感兴趣的老师来听。

报告时间：12月14日（周三）下午2:00

报告地点：小楼三楼大会议室

Title：Disrupted Structural and Functional  Brain Pathways for Attention Processing in Attention Deficit/Hyperactivity  Disorder (ADHD)

Abstract:ADHD  manifests in early childhood with symptoms of inattention,  hyperactivity,  impulsivity, or a combination. It affects about 5 - 8% of  school age children and an estimated 60% of those will maintain the disorder  into adulthood; affects cognitive, academic, behavioral, emotional, and social  functioning; and requests annual direct costs conservatively estimated $36 - $54  billion in the U.S. Over the past decades, most neuroimaging research in ADHD  has focused on the impulsive tendencies, implicating dysfunction within  fronto-striatal circuits. The neurobiological foundation of inattention, the  other most significant component of the disorder, has not yet been well  studied.This talk will introduce a  series of studies, which suggest that inappropriate development of the pulvinar  nuclei of thalamus in children with ADHD may induce the disrupted  pulvinar-cortical circuits for attention processing, and further contribute to  the pathophysiological mechanisms of inattention of the disorder. Based on the  findings of this series of studies, future studies can assess the impact of the  treatments on the connectivity and efficiency of the pulvinar-cortical circuits  for attention processing, and suggest effective intervention  strategies.

Biography of Dr. Xiaobo LiDr. Xiaobo Li is the Director for Image  Analysis Section at Gruss Magnetic Resonance Research Center (MRRC),Assistant Professor at Departments of Radiology,  Neuroscience, Psychiatry and Behavioral Sciences,Albert Einstein College of Medicine, Yeshiva  University,NY, USA.She has received a Ph.D in Computer-Aided Geometric Design at  University of Birmingham, UK, 2001-2004. Her current research has a strong focus  on MR brain imaging and application problems.  She has extensive theoretical and  practical experiences in developing and translating mathematical techniques to  quantitatively evaluate the structural and functional organizations in the human  brain using structural MRI, DTI, and fMRI. 

Her Research Interests  include:§Functional MRI analysis – developing and  translating refined quantitative mathematical and statistical methodologies for  functional organization analyses to elucidate the pathophysiological mechanisms  underlying normal brain development, and disorders such as Schizophrenia, ADHD,  Depression, etc.. §Computational Neuroanatomy – developing  refined quantitative mathematical measures of cortical shape development and  geometric shape modeling of brain structures using structural MRI and  DTI§Integrated analyses of brain structure and  function applying structural MRI, fMRI, DTI, PET, EEG/MEG measures and  psychological and psychopharmacological factors.§Clinical Applications:§Functional and anatomical developments of  language processing circuit and default-mode network system during normal brain  maturation and onset of Schizophrenia.§Functional and anatomical impairments in  visual- and auditory-language processing circuit in patients with Schizophrenia,  ADHD, Autism, Depression,  other inheritable mental disorders, and the genetic  high-risk children and adolescents§Pharmacological stimulant effects to the  efficiency of default-mode network system and cognition in ADHD and  Autism

Her Selected Recent Publications  in the Past Five YearsShugao Xia,

Xiaobo  Li*,Ariane E. Kimball, Mary S. Kelly, Iris Lesser, Craig Branch, 2011:  Thalamic Shape and Connectivity Abnormalities in Children with Attention  Deficit/Hyperactivity Disorder. Psychiatry Research Neuroimaging, in  press.

Xiaobo  Li,Molly Zimmerman, Mindy Kate, Richard Lipton, 2011: Stress Impact on  Hippocampal Morphology and Episodic/Working Memory in Non-demented Elder Adults.  Neurology, in press

Xiaobo  Li*,Venkatesh Alapati, Courtney Jackson, Shugao Xia, Hilary C. Bertisch,  Craig A. Branch, Lynn E. DeLisi, 2011: Structural Abnormalities in Language  Circuits in Genetic High-risk Subjects and Schizophrenia Patients. Psychiatry  Research Neuroimaging, in press.

Xiaobo  Li*,Lynn Delisi, 2011. Chapter 7: White Matter Abnormalities in  Schizophrenia Patients and Genetic High-risk Subjects. Schizophrenia Research:  Recent Advances. Nova Science Publishers INC., NY. Editor Tomiki Sumiyoshi.  ISBN: 978-1-61942-459

Xiaobo Li*,  Craig Branch, Lynn Delisi, 2010: Disturbed Functional Connectivity of Cortical  Activation during semantic discrimination in patients with schizophrenia and  subjects at genetic high-risk. Brain Imaging and Behavior, 4:  109-120.

Xiaobo Li*,Craig Branch,Lynn DeLisi, 2009. Language pathway  abnormalities in schizophrenia: a review of fMRI and other imaging  studies.Current Opinion in Psychiatry, (Invited review) 22:2,  131-139.

Xiaobo Li,  Craig Branch, Hilary Bertisch, Kyle Brown, Kamila Szulc, Babak Ardekani, Lynn  Delisi 2007a: An fMRI Study of Language Processing in People at High Genetic  Risk for Schizophrenia.Schizophrenia Research, 91: 62-72.

Xiaobo Li,Jiefeng Jiang, Wanlin Zhu, Tianzi Jiang, Chunshui Yu,  Manqiu Sui, Yufeng Wang. 2007b. Asymmetry of Prefrontal Cortical Convolution  Complexity in Males with Attention-Deficit/Hyperactivity Disorder Using Fractal  Information Dimension.Brain and Development, 29: 649-655.

Xiaobo Li,  Craig Branch, Babak Ardekani, Hilary Bertisch, Chindo Hicks, Lynn E. DeLisi,  2007d. fMRI Study of Language Activation in Schizophrenia, Schizoaffective  Disorder and in Individuals Genetically at High Risk.Schizophrenia  Research, 96: 14-24.         

      此致

 敬礼！                          

                     杨静                      

                     2011.12.13