各位老师：

您好！实验室张鸣沙老师邀请了Department of  Neuroscience, Brown University的Dr. Ji Dai做报告，欢迎感兴趣的老师和同学参加。

报告时间：3月14日（周五）下午2:00

报告地点：脑成像中心308会议室（大会议室）

报告题目：See the light:  Modulating salience by optogenetic stimulation in the nonhuman  primate

报告摘要：Optogenetics is a  recently developed method in which neurons are genetically modified to express  membrane proteins sensitive to light, enabling precisely targeted control of  neural activity. The temporal and spatial precision afforded by neural  stimulation by light holds promise as a powerful alternative to current methods  of neural control, which rely predominantly on electrical and pharmacological  methods, in both research and clinical settings. While the optogenetic approach  has been widely used in rodent and other small animal models to study neural  circuitry, its functional application in primate models has proven more  difficult. In contrast to the relatively large literature on the effects of  cortical electrical microstimulation in perceptual and decision making tasks,  previous studies of optogenetic stimulation in primates have not demonstrated  its utility in similar paradigms. Here we show that, in a visuospatial  discrimination task, optogenetic activation in the lateral intraparietal area  (LIP) induced significant and predictable biases in visual attention. In another  memory-guided saccade task, we also observed evidence of optogenetic stimulation  induced bias in monkey’s performance. Our  results demonstrate the power of optogenetics as a viable alternative to  electrical microstimulation for the precise dissection of the cortical pathways  of high-level processes in the primate brain.

报告人简介：

Education:Sep.2003–Jan.2010:       

Ph.D in Biophysics, Institute of Biophysics, Chinese Academy of Sciences.  Beijing, China Mentor: Yi WangDissertation:  Processing of luminance and contrast in primary visual cortex of  cat.Committee: Wu Li  (chair), Bing Li, Yuanye Ma, Mingliang Pu, Letian(Louis) Tao, Yan  Zhuo

Sep.1999–Jul.2003:       

 B. S. in Physics, Nanjing University. Nanjing, Jiangsu Province, China