各位老师，您好：

实验室邀请了Howard Hughes Medical Institute’s  Janelia Farm Research Campus的Zengcai Guo博士来实验室做报告，欢迎感兴趣的老师来听！

题目：From sensation to action: deconstruct  the neural circuit underlying a tactile decision in mice

时间：2月28日（本周五）下午2点

地点：小楼三楼大会议室

摘要：

Perceptual decisions involve  distributed cortical activity. Does information flow sequentially from one  cortical area to another, or do networks of interconnected areas contribute at  the same time? We delineate when and how activity in specific areas drives a  whisker-based decision in mice. We first developed a decision task with a  short-term memory component that temporally separated tactile “sensation” and  “action”. Using optogenetic inhibition (spatial resolution, 2 mm; temporal  resolution, 100 ms), we surveyed the neocortex for regions driving behavior  during specific behavioral epochs. Barrel cortex was critical for sensation.  During the short-term memory, unilateral inhibition of anterior lateral motor  cortex biased responses to the ipsilateral side. Consistently, barrel cortex  showed stimulus-specific activity during sensation, whereas motor cortex showed  choice-specific preparatory activity and movement-related activity, consistent  with roles in motor planning and movement. These results suggest serial  information flow from sensory to motor areas during perceptual decision  making.

报告人简历：

EDUCATION  AND RESEARCHPostdoctoral  Associate  2010-Current  Howard Hughes  Medical Institute’s Janelia Farm Research  Campus.

PhD in Applied  Mathematics  2010Harvard University,  Cambridge,

 MAMaster in Solid  Mechanics   2004  Tsinghua University,  Beijing, China

Bachelor of  Engineering    2002  Tsinghua University,  Beijing, China

PUBLICATIONS

1.ZV Guo, SA Hires, N Li, DH, O?Connor, T  Komiyama, E. Ophir, D Huber, C Bonardi, K Morandell, D Gutnisky, S Peron, N Xu,  J Cox, K Svoboda. Procedures for behavioral experiments in head-fixed  mice. Plos one. 2014, in press.

2.ZV Guo*, N Li*, D Huber, E Ophir, D  Gutnisky, JT Ting, G Feng and K Svoboda. Flow of cortical activity underlying a  tactile decision in mice. Neuron. 2014, 179-194.

3.DH O?Connor*, SA Hires*, ZV  Guo, N Li, J Yu, Q Sun, D Huber and K Svoboda. Neural coding during active  somatosensation revealed using illusory touch. Nature  Neuroscience. 2013, 16, 958-965.

4.Z Wei, ZV Guo, L Dudte, H  Liang and L Mahadevan. Geometric mechanics of periodic pleated  origami. Physical Review Letters. 2013, 110,  215501-5.

5.K Askin*, C Shen*, ZV Guo and  S Ramanathan. Controlling interneuron activity in Caenorhabditis elegans to  evoke chemotactic behavior. Nature. 2012, 490,  273–277.

6.ZV Guo, AC Hart and S Ramanathan. Optical  interrogation of neural circuits in Caenorhabditis elegans. Nature  Methods. 2009, 6, 891-896.

7.ZV Guo and L Mahadevan. Limbless undulatory  propulsion on land. Proceedings of the National Academy of  Sciences. 2008, 105(9), 3179-3184.

8.Z Guo and W Yang. MPM/MD handshaking  method for multiscale simulation and its application to high energy cluster  impacts. International Journal of Mechanical Sciences, 2006,  48(2), 145–159.

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