各位老师：

您好！实验室邀请了Norwegian University of Science and  Technology (NTNU)的Sheng-Jia Zhang博士来实验室做报告，欢迎感兴趣的老师来听！

题目：Optogenetic Decoding of the Neural  Circuit of the Brain’s GPS

时间：9月26日（周四）上午10点

地点：小楼三楼大会议室

摘要：Both the hippocampus and the medial  entorhinal cortex are key components of the brain’s map of the spatial  environment. The spatial map or the brain’s GPS contains a number of  functionally specialized cell types, including, in the hippocampus, place cells,  and, in the medial entorhinal cortex, grid cells, head-direction cells, and  border cells. However, the functional interaction between a single hippocampal  place map and the multiple medial entorhinal spatial maps is poorly understood.  Hippocampal place signals may be generated by transformation of spatial input  from the medial entorhinal cortex but which cell types contribute to this  process remains elusive, given that only a subset of the entorhinal projection  neurons target the hippocampus. In this lecture, I will introduce how a combined  optogenetic-electrophysiological strategy is initiated to estimate the identity  and quantity of medial entorhinal functional cell types with monosynaptic  projections to the hippocampus; I will talk about the power and promise of my  self-developed retrograde virus for genetically tagging project-targeted and  circuit-specific intervention of the hippocampal-entorhinal space memory  circuit; I will show you both gain-of-function and loss-of-function optogenetic  control over the space memory circuit; I will suggest that place cells are  generated by convergence of signals from multiple functional cell types, with  grid cells as the main contributor; Finally, I will describe the therapeutic  application of translational optogenetics to neurologic diseases as well as the  decisive role of optogenetics in brain activity mapping project. 

报告人简历：

Education

05/2003 - 06/2006    Ph.D. in Neurobiology      

University of Heidelberg,  Germany

09/1987 - 07/1990  M.S.  in Virology and Molecular Biology     

Wuhan University,  China

09/1983 - 07/1987    B.S. in Virology and Molecular Biology      Wuhan University,  China

Research Experience  08/2010 - Present    Group Leader      

Kavli Institute for Systems Neuroscience,  Centre for Neural Computation (CNC), Norwegian University of Science and  Technology (NTNU), Norway11/2008 - 07/2010       Research Scientist      Kavli Institute for Systems Neuroscience,  Centre for Neural Computation (CNC), Norwegian University of Science and  Technology (NTNU), Norway07/2006 - 10/2008       Postdoctoral Fellow   Department of Neurobiology, Interdisciplinary  Center for Neurosciences (IZN), University of Heidelberg, Germany

     此致

敬礼！

认知神经科学与学习国家重点实验室

2013年9月22日